Knee surgery and a back complaint meant Jamison had an interrupted build-up to the 2012 season.
He missed Carlton's first two games, then suffered shoulder problems later in the year.
The shoulder issues curtailed his ability to match-up on the competition's best forwards and forced him to sit out the Blues' last three matches.
But the 26-year-old, who has flown out to Arizona with his teammates for a two-week high-altitude training camp, is confident that his body is once again in good shape.
"Having no surgery (during the off-season) was certainly a huge benefit," Jamison said at Melbourne Airport on Friday.
"You don't start behind the eight-ball, so I'm feeling pretty fit and looking to work on that in the next few weeks.
"You're can't compare pre-seasons when you have surgery in the off-season and then you don't."
One of Carlton's most consistent backmen when fit, Jamison is likely to play a key role in Mick Malthouse's defence-first game plan.
"It's something we look forward to in the backline, knowing that we'll probably have more support than we have in the past," he said.
"And our roles will certainly be valued and privileged within the team.
"It is a fresh start for everyone. Mick knows how we all played last year, so he has a little bit to lean on.
"But guys might be thrown around in different positions, so it's pretty exciting."
Another Carlton defender on the comeback trail from a serious injury is Andrew McInnes.
The 20-year-old made his debut against Collingwood in round 15, showing skill and poise across half-back.
He was selected for eight games in all, but his season came to a devastating halt when he ruptured the anterior cruciate ligament in his right knee in the opening seconds of Carlton's shock loss to Gold Coast at Metricon Stadium in round 22.
"The best moment was probably when the final siren sounded in my first game against Collingwood," McInnes told carltonfc.com.au.
The worst would have been the final siren in the Gold Coast game.
"When the siren went against Collingwood I was pretty numb. I remember having a look around and seeing some of the boys celebrating, then looking at the crowd - everything seemed to happen so fast.
"When the siren went against Gold Coast I already knew that I'd done my knee and the season was basically over."
Although he won't play again until May at the earliest, McInnes has already been motivated by the message Malthouse has brought to the club.
"Mick seems to me to be really genuine," he said.
"He just wants us to build a trust and respect between each other, and the more he talks the more he drills that into us."
